WANT TO GET RID OF THE STRESS CRACKING OF THE LIDDING FOIL OF YOUR BLISTER PACKINGS, THEREBY BOOSTING YOUR QUALITY AND BRAND NAME WITHOUT HAVING TO INVEST A LOT?
It is no more uncommon to hear about the cracking of Blister Packings prematurely. There may be many reasons behind, however, Cracking of the duly filled Blister Packed Strip of Tablets Or Capsule invites troubles such as rejection of batches, notices of non-compliances, unwanted shutdowns at times and finally lost revenue.
US-FDA’s recent report published on website (period Oct 1st 2020 through Sep 30th 2021) enlists many cases of non-compliances under 21 CFR 820.50, which talks about pharma companies not being able to evaluate or identify the potentials and limitations of the manufacturing equipments/ machineries with respect to the User Requirement Specifications.
One of the key area, which we often tend to underestimate while discussing the proper and long lasting sealing of the blister package, is the Knurling Pattern.
A too-aggressive sealing die combined with high pressure and high line speed might lead to stress cracking of the lidding foil and compromise the seal integrity. Many a times, this might become noticeable only in long-term, hence many get unnoticed even during the preliminary leak test with a methylene blue bath.
It is very important that the sealing tool should have a very good flatness and appropriate knurling. Hence, one should use pressure-sensitive tape to assure planarity of the tool. One may want to vary the type of knurl depending on the type of lidding you run. Depending on the web width, the knurls can be varied too. Ie smaller knurls on a narrow web (as the air can escape more easily), whereas, slightly larger knurls on a wider web, to allow some place for the entrapped air to go.
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